The children involved in a crash in Coolup on Saturday afternoon are understood to be twins, their sibling and a female friend.
The 17-year-old female driver and a 17-year-old male passenger both died at the scene.
Police say a Holden Commodore sedan was travelling south on Brownes Road around 7.48pm on Saturday when it left the road and rolled several times.
Two other male passengers, aged 10 and 17, both received serious injuries and were conveyed to Perth Children's Hospital and Royal Perth Hospital.
They both remain in a stable condition.
Investigators are appealing for anyone that witnessed the crash, or that saw the Commodore prior to the crash to contact Crime Stoppers by calling 1800 333 000 or by making a report online at crimestopperswa.com.au.