Fire crews were called to a blaze at Peel Caravan Park on Pinjarra Road in Furnissdale on Monday evening.
The fire broke out in a caravan about 9.30pm.
Firefighters from Mandurah and West Murray attended with the fire quickly brought under control, but not before it destroyed the caravan.
St John Ambulance was called for two people suffering smoke inhalation.
Police were also requested to attend the incident.
Investigations are under way.